Are you healthy and looking to help advance medical science?

You may be eligible to participate in a bipolar disorder clinical study, and could be compensated for your time.

Are you healthy and looking to help advance medical science? You may be eligible to participate in a bipolar disorder clinical study, and could be compensated for your time.

What is a clinical trial? Is participating in a clinical trial right for you? Learn more

Bipolar Disorder Clinical Trial

NCT00001174 | Observational

Are you healthy and looking to help advance medical science?

You may be eligible to participate in a bipolar disorder clinical study, and could be compensated for your time.

Are you healthy and looking to help advance medical science? You may be eligible to participate in a bipolar disorder clinical study, and could be compensated for your time.

Recruiting

Male & Female

18 Years +

This study is looking to recruit 6000 Participants

This study looks to identify genes that may affect a person's chances of developing bipolar disorder (BP) and related conditions.

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Details for the study

Population

community samples and clinical samples

Brief Title

Evaluation of the Genetics of Bipolar Disorder

Official Title

Bipolar Genetics: A Collaborative Study

Brief Summary

This study looks to identify genes that may affect a person's chances of developing bipolar <br /> disorder (BP) and related conditions.

Detailed Description

Bipolar affective disorder is a severe, heritable condition affecting about one percent of

the population. The mode of inheritance is poorly understood and probably involves multiple
loci of small to moderate effect. In this project, we use genetic mapping and sequencing
methods to identify genetic markers and variations that contribute to the risk of bipolar
disorder. Individuals diagnosed with bipolar disorder are studied, along with their
relatives. Phenotypic information obtained from clinical interviews and family history is
correlated with genotypic information obtained from genetic marker and sequencing methods.
The goal is to identify genes involved in bipolar disorder and related conditions so that
better methods of diagnosis, treatment, and prevention can be developed.

Outcome Measures

Outcome measures are the tests that investigators perform to prove whether or not a treatment being tested in a clinical trial is having any effect.

Primary

Diagnosis of bipolar disorder or related mental illness by direct interview

Psychiatric diagnosis is based on systematic review of established signs and symptoms, using an instrument designed to elicit retrospective information of known reliability, supplemented with information from family informants, any medical records, and by dimensional symptom measures.

Diagnosis is established primarily at the initial study visit. Participants who consent to recontact are re-evaluated when they or family informants report events that could lead to a revised diagnosis.

Study Criteria

INCLUSION CRITERIA:

Age > 18 yr

Able to provide informed consent

Bipolar disorder or related conditions not attributable to substance abuse, neurological
disease; or a 1st or 2nd degree relative of an enrolled participant. Related conditions are
defined as those found more often among relatives of people with bipolar disorder or which
have been shown to be genetically correlated with bipolar disorder through molecular
genetic studies. These include major depression, schizophrenia, panic disorder, and
attention deficit hyperactivity disorder.

Able to safely provide a blood or saliva sample

EXCLUSION CRITERIA:

Active alcohol or substance abuse.

NIMH employees/staff and their immediate family members will be excluded from the study per
NIMH policy.